Which of the following factors is NOT one of the 10 significant risk factors identified in the INTERSTROKE study?

The INTERSTROKE study aimed to identify the major risk factors contributing to stroke across different populations. Among the ten significant risk factors identified, aspects such as current smoking, high blood pressure, and alcohol use are included because they have a clear and substantial association with stroke risk.

Heart failure, while it is a serious cardiovascular condition and can increase the risk of various complications, is not classified as one of the primary risk factors for stroke within the context of this specific study. Instead, the focus was on modifiable lifestyle factors and medical conditions that directly increase the likelihood of stroke occurrence. Thus, listing heart failure as one of the significant risk factors deviates from the findings of the INTERSTROKE study.