What is a common side effect associated with naltrexone?

Naltrexone is an opioid receptor antagonist primarily used in the management of alcohol and opioid dependence. A widely recognized side effect associated with the use of naltrexone is nausea. This occurs because naltrexone can influence the gastrointestinal system by affecting opioid receptors that play a role in various bodily functions, including the regulation of nausea and gastrointestinal motility. Nausea may vary in intensity among individuals but is reported frequently enough to be classified as a common side effect.

Understanding the context of naltrexone's mechanism can help clarify why nausea is prevalent among users. As naltrexone blocks the euphoric effects of opioids, its action can lead to a response in the body that results in gastrointestinal discomfort, manifesting as nausea. This side effect can sometimes deter individuals from adhering to their prescribed naltrexone regimen, emphasizing the importance of monitoring and managing side effects during treatment.