In the DiRECT study, what percentage of participants achieved remission to a non-diabetic state at 12 months?

The DiRECT study, which stands for Diabetes Remission Clinical Trial, aimed to assess the effectiveness of a structured weight management program in individuals with Type 2 diabetes. A key outcome of this study was the percentage of participants who were able to achieve remission to a non-diabetic state after 12 months.

The correct response indicates that 46% of the participants successfully reached remission, showcasing the significant impact of lifestyle interventions, particularly weight loss through dietary changes and increased physical activity. This high percentage highlights the potential for non-pharmacological approaches in managing and reversing Type 2 diabetes.

Participants in the DiRECT study underwent a low-calorie diet initially followed by support for weight maintenance, demonstrating that substantial weight loss can lead to significant metabolic improvements, including glycemic control. The findings from this study serve as an important reminder of the power of lifestyle modifications in the treatment of Type 2 diabetes and the possibility of achieving remission.