Which risk factor contributes most to cardiovascular disease according to the INTERHEART study?

The INTERHEART study identified smoking as a significant risk factor contributing to cardiovascular disease, highlighting its substantial impact on heart health. Smoking influences cardiovascular risk through various mechanisms, including the promotion of atherosclerosis, increased blood pressure, and adverse effects on blood vessel function. The study found that current smokers had a significantly higher risk of myocardial infarction compared to nonsmokers.

While physical inactivity, obesity, and unhealthy diet also contribute to cardiovascular disease, the INTERHEART study prioritized smoking as a predominant factor based on the strength of the associated risk and the evidence gathered across various populations. This insight underscores the importance of smoking cessation programs and public health initiatives aimed at reducing tobacco use as key components in lowering cardiovascular disease incidence.